Raf-1 activates MAP kinase-kinase

John Kyriakis, Harald App, Xianfeng Zhang, +4

Nature

Signal TransductionMolecular PhysiologySignaling PathwayCell RegulationReceptor Tyrosine Kinase +3

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang, +4

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryRtk ActivityMedicine +12

Flk-1 as a target for tumor growth inhibition.

L M Strawn, Gerald McMahon, Harald App, +15

PubMed

Endothelial CellsCancer BiologyTumor BiologyAngiogenesisReceptor Tyrosine Kinase +16

Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase:  Structure−Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins

Aviv Gazit, Harald App, Gerald McMahon, +3

Journal of Medicinal Chemistry

Pharmaceutical ScienceIndole TyrphostinsPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +17

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.

Benjamin L. Turner, Ulf R. Rapp, Harald App, +3

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismImmune System +17

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.

Manuela Baccarini, David M. Sabatini, Harald App, +2

The EMBO Journal

Signal TransductionRaf-1 Proto-oncogene ProductSignaling PathwayCell RegulationNatural Sciences +8

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

Harald App, Ronen Hazan, Asher Zilberstein, +3

Molecular and Cellular Biology

Egf Signal TransductionEpidermal Growth FactorDevelopmental BiologySignal TransductionSignaling Pathway +12

Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.

Jakob Troppmair, Joseph T. Bruder, Harald App, +5

PubMed

Purification and Characterization of Neutral Trehalase from the Yeast ABYS1 Mutant

Harald App, Helmut Holzer

Journal of Biological Chemistry

Yeast Abys1 MutantCellular EnzymologyBiochemistryTrehalose.neutral TrehalaseNatural Sciences +13

Insulin activates the Raf-1 protein kinase.

Perry J. Blackshear, D.M. Haupt, Harald App, +1

Journal of Biological Chemistry

Insulin ReceptorsCellular PhysiologyNm InsulinInsulin SignalingReceptor Tyrosine Kinase +14