How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

Radek Jorda, Denisa Hendrychová, Jiří Voller, +3

Journal of Medicinal Chemistry

Preparation and Standardisation of Smoke-Water for Seed Germination and Plant Growth Stimulation

Shubhpriya Gupta, Jakub Hrdlička, Nelson Ngoroyemoto, +6

Journal of Plant Growth Regulation

EngineeringBotanyPlant ProductionAgricultural EconomicsCrop Establishment +4

A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors

Tomáš Gucký, Radek Jorda, Marek Zatloukal, +6

Journal of Medicinal Chemistry

Chemoprevention StrategyPharmacotherapyPharmaceutical ChemistryMedicinal ChemistryCancer Drug Development +14

Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines

Tomáš Gucký, Iveta Fryšová, Jan Slouka, +2

European Journal of Medicinal Chemistry

HeterocyclicCyclocondensation ReactionOrganic ChemistryPart XiiiChemistry +4

Discovery of <i>N</i>²-(4-Amino-cyclohexyl)-9-cyclopentyl-<i>N</i>⁶-(4-morpholin-4-ylmethyl-phenyl)-<i>9H</i>-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations

Tomáš Gucký, Eva Řezníčková, Tereza Radošová Muchová, +9

Journal of Medicinal Chemistry

Molecular BiologyCell DeathFlt3 MutationsTumor BiologyMyeloid Neoplasia +16

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases

Marek Zatloukal, Radek Jorda, Tomáš Gucký, +7

European Journal of Medicinal Chemistry

2,6,9-Trisubstituted PurinesMedicineCellular PharmacologyMultiple Cyclin-dependent KinasesVitro Biological Evaluation +4

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

Mariusz Mojzych, Veronika Šubertová, Anna Bielawska, +6

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)HeterocyclicBiochemistryNatural Sciences +9

Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

Christine Haider, Markus Grubinger, Eva Řezníčková, +10

Molecular Cancer Therapeutics

Inducing ChemoresistanceTumor BiologyOncologyMedicineLiver Physiology +11

Trisubstituted Pyrazolopyrimidines as Novel Angiogenesis Inhibitors

Sabine B. Weitensteiner, Johanna Liebl, Vladimı́r Kryštof, +6

PLoS ONE

Quantification of karrikins in smoke water using ultra-high performance liquid chromatography–tandem mass spectrometry

Jakub Hrdlička, Tomáš Gucký, Ondřej Novák, +4

Plant Methods