How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

Radek Jorda, Denisa Hendrychová, Jiří Voller, +3

Journal of Medicinal Chemistry

A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors

Tomáš Gucký, Radek Jorda, Marek Zatloukal, +6

Journal of Medicinal Chemistry

Chemoprevention StrategyPharmacotherapyPharmaceutical ChemistryMedicinal ChemistryCancer Drug Development +14

Discovery of <i>N</i>²-(4-Amino-cyclohexyl)-9-cyclopentyl-<i>N</i>⁶-(4-morpholin-4-ylmethyl-phenyl)-<i>9H</i>-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations

Tomáš Gucký, Eva Řezníčková, Tereza Radošová Muchová, +9

Journal of Medicinal Chemistry

Molecular BiologyCell DeathFlt3 MutationsTumor BiologyMyeloid Neoplasia +16

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases

Marek Zatloukal, Radek Jorda, Tomáš Gucký, +7

European Journal of Medicinal Chemistry

2,6,9-Trisubstituted PurinesMedicineCellular PharmacologyMultiple Cyclin-dependent KinasesVitro Biological Evaluation +4

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines

Aleš Imramovský, Radek Jorda, Karel Pauk, +4

European Journal of Medicinal Chemistry

MedicineInduce ApoptosisCell DeathAnti-cancer AgentPharmacology

Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC)

Eva Řezníčková, Soňa Krajčovičová, Miroslav Peřina, +3

European Journal of Medicinal Chemistry

Mixed-phenotype Acute LeukemiaImmunologyCell DeathTumor BiologyMyeloid Neoplasia +15

Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

Christine Haider, Markus Grubinger, Eva Řezníčková, +10

Molecular Cancer Therapeutics

Inducing ChemoresistanceTumor BiologyOncologyMedicineLiver Physiology +11

Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines

Radek Jorda, Eva Řezníčková, Urszula Kiełczewska, +7

European Journal of Medicinal Chemistry

MedicineAnti-cancer AgentDrug DevelopmentVitro ActivityPharmacology +4

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines

Vaida Milišiūnaitė, Eglė Arbačiauskienė, Eva Řezníčková, +6

European Journal of Medicinal Chemistry

HeterocyclicOrganic ChemistryAnti-mitotic ActivityHeterocycle ChemistryPharmacology +1

Exploitation of new structurally diverse <scp>d</scp>-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential

Nuno M. Xavier, Alexandre Porcheron, Daniela Batista, +4

Organic & Biomolecular Chemistry