Radek Jorda

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Alessio Nocentini et al. · European Journal of Medicinal Chemistry · 2019 · 106 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

Radek Jorda, Denisa Hendrychová, Jiří Voller et al. · Journal of Medicinal Chemistry · 2018 · 96 citations · Full text

Pyrazolo[4,3-<i>d</i>]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity

Radek Jorda, Libor Havlı́ček, I.W. McNae et al. · Journal of Medicinal Chemistry · 2011 · 85 citations · Full text

Chemoprevention Strategy, Pharmacotherapy, Pharmaceutical Chemistry +20

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Soňa Krajčovičová, Radek Jorda, Denisa Hendrychová et al. · Chemical Communications · 2018 · 57 citations

Bioorganic Chemistry, Fast Formation, Chemical Biology +18

Degradation of cytokinins by maize cytokinin dehydrogenase is mediated by free radicals generated by enzymatic oxidation of natural benzoxazinones

Jitka Frébortová, Ondřej Novák, Ivo Frébort et al. · The Plant Journal · 2009 · 52 citations

Engineering, Molecular Biology, Stable Free Radical +16