Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616

Tomoki Bo, Tohru Yamamori, Motofumi Suzuki, +3

Biochemical and Biophysical Research Communications

Signal TransductionMitochondrial FunctionNatural SciencesMolecular BiologySerine 616 +8

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation

Tohru Yamamori, Satoshi Ike, Tomoki Bo, +7

Molecular Biology of the Cell

MitophagyMolecular BiologyCell DeathCytoskeletonRadiation Biology +16

NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells

Yuri Sakai, Tohru Yamamori, Yoji Yoshikawa, +5

Free Radical Research

Dna DamageNadph OxidaseLipid PeroxidationRadiation EffectCell Death +18

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Hironobu Yasui, Kumiko Yamamoto, Motofumi Suzuki, +8

Cancer Letters

Radiation-induced CellLipophilic Triphenylphosphonium DerivativesRadiation EffectCell DeathRadiopharmaceutical Therapy +10

MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis

Motofumi Suzuki, Tohru Yamamori, Tomoki Bo, +2

Translational Oncology

Bromodomain and extraterminal domain inhibition synergizes with WEE1‐inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer

Yuta Takashima, Eiki Kikuchi, Junko Kikuchi, +9

International Journal of Cancer

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro

Kenichiro Maeda, Hironobu Yasui, Taeko Matsuura, +6

Journal of Radiation Research

Relative Biological EffectivenessSpot-scanning Proton IrradiationRadiation EffectRadiation ExposureRadiation Biology +14

Influence on [18F]FDG uptake by cancer cells after anti-PD-1 therapy in an enforced-immune activated mouse tumor

Mayu Tomita, Motofumi Suzuki, Yusuke Kono, +4

EJNMMI Research

In Vitro and In Vivo Cell Uptake of a Cell-Penetrating Peptide Conjugated with Fluorescent Dyes Having Different Chemical Properties

Hideo Takakura, Honoka Sato, Kohei Nakajima, +2

Cancers

NanomedicineDye-cpp ConjugatesEngineeringBiochemistryPolymer-drug Conjugate +10

Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer

Motofumi Suzuki, Mayuka Anko, Maki Ohara, +2

International Journal of Radiation Oncology*Biology*Physics

Tumor BiologyMitophagyG2 Checkpoint ActivationPancreatic CancerCell Autophagy +11