Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616

Tomoki Bo, Tohru Yamamori, Motofumi Suzuki, +3

Biochemical and Biophysical Research Communications

Signal TransductionMitochondrial FunctionNatural SciencesMolecular BiologySerine 616 +8

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation

Tohru Yamamori, Satoshi Ike, Tomoki Bo, +7

Molecular Biology of the Cell

MitophagyMolecular BiologyCell DeathCytoskeletonRadiation Biology +16

NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells

Yuri Sakai, Tohru Yamamori, Yoji Yoshikawa, +5

Free Radical Research

Dna DamageNadph OxidaseLipid PeroxidationRadiation EffectCell Death +18

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Hironobu Yasui, Kumiko Yamamoto, Motofumi Suzuki, +8

Cancer Letters

Radiation-induced CellLipophilic Triphenylphosphonium DerivativesRadiation EffectCell DeathRadiopharmaceutical Therapy +10

MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis

Motofumi Suzuki, Tohru Yamamori, Tomoki Bo, +2

Translational Oncology

Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts

Tohru Yamamori, Tomoya Sasagawa, Osamu Ichii, +5

Journal of Radiation Research

Radiation EffectMitochondrial BiologyMouse FibroblastsRadiation BiologyRedox Biology +20

Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells

Tomoki Bo, Tohru Yamamori, Kumiko Yamamoto, +3

Biochemical and Biophysical Research Communications

Cell DivisionMitochondrial FunctionRadiation BiologyMedicineRadiation Effect +10

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence

Tomoki Bo, Sho Kobayashi, Osamu Inanami, +4

Translational Oncology

Neutral Amino AcidRadiation EffectCell DeathCancer BiologyTumor Biology +15

Radiation-induced abnormal centrosome amplification and mitotic catastrophe in human cervical tumor HeLa cells and murine mammary tumor EMT6 cells

Masaki Fujimoto, Tomoki Bo, Kumiko Yamamoto, +3

Journal of Clinical Biochemistry and Nutrition

Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS

Tatsuya Deguchi, Kenji Hosoya, Shango Kim, +6

Molecular Therapy — Oncolytics

Cancer Stem-like CellsOncologyMitochondrial FunctionRadiation TherapyMedicine +12