Lubomir V. Nechev

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.7K citations

Lipid Preparation, Nanomedicine, Engineering +3

RNAi-mediated gene silencing in non-human primates

Tracy Zimmermann, Amy C. H. Lee, Akin Akinc et al. · Nature · 2006 · 1.3K citations

Genetics, Rnai-mediated Gene, Antisense Therapy +1

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

Cell-based Drug Delivery, Nanomedicine, Lipid Preparation +9

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson et al. · Proceedings of the National Academy of Sciences · 2008 · 635 citations · Full text

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

John P. DeVincenzo, Jeff Cehelsky, Rene Alvarez et al. · Antiviral Research · 2008 · 245 citations

Respiratory Syncytial Virus, Neurovirology, Pharmacology +9