Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen, +38

Nature Biotechnology

Lipid PreparationNanomedicineEngineeringRational DesignGene Delivery +1

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, +29

Nature Biotechnology

Cell-based Drug DeliveryNanomedicineLipid PreparationEngineeringRnai Therapeutics +7

Lipid-like materials for low-dose, in vivo gene silencing

Kevin T. Love, Kerry P. Mahon, Christopher G. Levins, +17

Proceedings of the National Academy of Sciences

In Vivo Gene TherapyImmunologyGene DeliveryBiomedical EngineeringTherapeutics +16

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

Teresa Coelho, David Adams, Ana Silva, +28

New England Journal of Medicine

Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus

John P. DeVincenzo, Tom Wilkinson, Akshay Vaishnaw, +15

American Journal of Respiratory and Critical Care Medicine

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

John P. DeVincenzo, Jeff Cehelsky, Rene Alvarez, +7

Antiviral Research

Respiratory Syncytial VirusNeurovirologyPharmacologyAntiviral ResponseNovel Rnai +7

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

Rene Alvarez, Sayda M. Elbashir, Todd Borland, +16

Antimicrobial Agents and Chemotherapy

Viral ReplicationRespiratory Virus ImmunityPotent Antiviral StrategyImmunologyMolecular Biology +14

Respiratory Syncytial Virus G Protein and G Protein CX3C Motif Adversely Affect CX3CR1+ T Cell Responses

Jennifer L. Harcourt, Rene Alvarez, Les Jones, +3

The Journal of Immunology

InflammationViral ReplicationRsv G ProteinImmunologyViral Pathogenesis +11

Diagnostic Approach for Differentiating Infected from Vaccinated Poultry on the Basis of Antibodies to NS1, the Nonstructural Protein of Influenza A Virus

Terrence M. Tumpey, Rene Alvarez, David E. Swayne, +1

Journal of Clinical Microbiology

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

James S. Butler, Amy Chan, Susete Costelha, +18

Amyloid

Translational MedicineAttr AmyloidosisTtr AmyloidRna InterferenceLiver Physiology +11