Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

Yoelvis García‐Mesa, Taylor R. Jay, Mary Ann Checkley, +6

Journal of NeuroVirology

Primary MicrogliaReactive HivImmunologyImmune RegulationImmunodominance +21

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

Biswajit Das, Curtis Dobrowolski, Benjamin G. Luttge, +9

Proceedings of the National Academy of Sciences

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

Kien Nguyen, Biswajit Das, Curtis Dobrowolski, +1

mBio

Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles

Marine Z. C. Hatit, Melissa P. Lokugamage, Curtis Dobrowolski, +11

Nature Nanotechnology

NanoparticlesEngineeringNanobiotechnologyNano-drug DeliveryVivo Mrna Delivery +2

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

Julie K. Jadlowsky, Julian Y. Wong, Amy C. Graham, +5

Molecular and Cellular Biology

Viral ReplicationRna Polymerase IiImmunologyMolecular BiologyTranscriptional Regulation +19

Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

Jeffrey S. Miller, Zachary Davis, Erika S. Helgeson, +18

Nature Medicine

Treatment And PreventionHuman RetrovirusImmunologyAntiviral ResponseIl-15 Superagonist N-803 +7

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

Uri Mbonye, Giridharan Gokulrangan, Manish Datt, +4

PLoS Pathogens

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

David Alvarez-Carbonell, Yoelvis García‐Mesa, Stephanie Milne, +4

Retrovirology

Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation

Eileen P. Scully, Monica Gandhi, Rowena Johnston, +19

The Journal of Infectious Diseases

Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery

Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, +9

Nature Nanotechnology

Cell HeterogeneityMedicineSingle-cell GenomicsNano-drug DeliveryGene Delivery +3