iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

Frank Cichocki, Ryan Bjordahl, Svetlana Gaidarova, +19

Science Translational Medicine

Cell TherapyImmunologyNk CellsVivo Tumor ControlImmunoediting +17

Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu

Ankur H. Shah, Bharatwaj Sowrirajan, Zachary Davis, +4

Cell Host & Microbe

Human RetrovirusImmunologyAntiviral ResponseChronic Viral InfectionHiv +4

Generation of BiKEs and TriKEs to Improve NK Cell-Mediated Targeting of Tumor Cells

Martin Felices, Todd Lenvik, Zachary Davis, +2

Methods in molecular biology

Cancer ImmunosurveillanceImmunologyNk Cell-mediated TargetingTumor CellsImmune Checkpoint Inhibitor +7

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Karrune Woan, Hansol Kim, Ryan Bjordahl, +28

Cell stem cell

Cell TherapyAdaptive Nk CellsAdaptive Immune SystemImmunologyAutoimmunity +7

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

Jeffrey P. Ward, Zachary Davis, Jason L. DeHart, +6

PLoS Pathogens

Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37

Dhifaf Sarhan, Keli L. Hippen, Amanda Lemire, +10

Cancer Immunology Research

Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

Jeffrey S. Miller, Zachary Davis, Erika S. Helgeson, +18

Nature Medicine

Treatment And PreventionHuman RetrovirusImmunologyAntiviral ResponseIl-15 Superagonist N-803 +7

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

Zachary Davis, Andrew C. Cogswell, Hamish W. Scott, +7

PLoS Pathogens

ImmunologyNk CellsAntigen ProcessingCd4 T Cell ResponsesNatural Killer Cells +15

Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

Frank Cichocki, Jodie P. Goodridge, Ryan Bjordahl, +17

Blood

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Frank Cichocki, Ryan Bjordahl, Jodie P. Goodridge, +20

Nature Communications