Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni, Martina Chiu, Fabrizio Accardi, +22

Blood

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Stefania Raimondo, Laura Saieva, Emanuela Vicario, +6

Journal of Hematology & Oncology

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Paola Storti, Marina Bolzoni, Gaetano Donofrío, +17

Leukemia

Tumor BiologyHypoxia-inducible FactorTumoral GrowthMedicineHypoxia (Medicine) +9

Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma

Alberto L. Horenstein, Valeria Quarona, Denise Toscani, +5

Molecular Medicine

New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics

Nicola Giuliani, Gina Lisignoli, Marina Magnani, +9

Stem Cells International

Tissue EngineeringSclerostinEngineeringAdult Stem CellBone Repair +18

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

Marina Bolzoni, Gaetano Donofrío, Paola Storti, +14

Leukemia

Bone Morphogenic ProteinCell SignalingMyeloma CellsCell BiologyMedicine +6

Microvesicles released from multiple myeloma cells are equipped with ectoenzymes belonging to canonical and non-canonical adenosinergic pathways and produce adenosine from ATP and NAD⁺

Fabio Morandi, Danilo Marimpietri, Alberto L. Horenstein, +9

OncoImmunology

Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules

Marina Bolzoni, Paola Storti, Sabrina Bonomini, +7

Experimental Hematology

InflammationHematological MalignancyMedicineCell AdhesionImmunology +6

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

Federica Costa, Denise Toscani, Antonella Chillemi, +14

Oncotarget

The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors

Denise Toscani, Carla Palumbo, Benedetta Dalla Palma, +12

Journal of Bone and Mineral Research