Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

Marina Bolzoni, Martina Chiu, Fabrizio Accardi, +22

Blood

Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation

Nicola Giuliani, Marzia Ferretti, Marina Bolzoni, +9

Leukemia

Hematological MalignancyBone Marrow FailureMedicineApoptosisImmunology +9

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Paola Storti, Marina Bolzoni, Gaetano Donofrío, +17

Leukemia

Tumor BiologyHypoxia-inducible FactorTumoral GrowthMedicineHypoxia (Medicine) +9

Angiogenesis and Multiple Myeloma

Nicola Giuliani, Paola Storti, Marina Bolzoni, +2

Cancer Microenvironment

AngiogenesisHematologyPathologyMyelopoiesisMultiple Myeloma +3

New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics

Nicola Giuliani, Gina Lisignoli, Marina Magnani, +9

Stem Cells International

Tissue EngineeringSclerostinEngineeringAdult Stem CellBone Repair +18

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

Marina Bolzoni, Gaetano Donofrío, Paola Storti, +14

Leukemia

Bone Morphogenic ProteinCell SignalingMyeloma CellsCell BiologyMedicine +6

Microvesicles released from multiple myeloma cells are equipped with ectoenzymes belonging to canonical and non-canonical adenosinergic pathways and produce adenosine from ATP and NAD⁺

Fabio Morandi, Danilo Marimpietri, Alberto L. Horenstein, +9

OncoImmunology

Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules

Marina Bolzoni, Paola Storti, Sabrina Bonomini, +7

Experimental Hematology

InflammationHematological MalignancyMedicineCell AdhesionImmunology +6

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

Federica Costa, Denise Toscani, Antonella Chillemi, +14

Oncotarget

Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease

Katia Todoerti, Gina Lisignoli, Paola Storti, +15

Experimental Hematology

Regenerative MedicineBone Morphogenic ProteinDistinct Transcriptional ProfilesImmunologyBone Homeostasis +4