Shin Takusagawa

Absorption, Metabolism and Excretion of [14C]Mirabegron (YM178), a Potent and Selective β3-Adrenoceptor Agonist, after Oral Administration to Healthy Male Volunteers

Shin Takusagawa, Jan Jaap van Lier, Katsuhiro Suzuki et al. · Drug Metabolism and Disposition · 2012 · 62 citations

<i>In vitro</i>inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist

Shin Takusagawa, Aiji Miyashita, Takafumi Iwatsubo et al. · Xenobiotica · 2012 · 50 citations

Development and validation of LC–MS/MS methods for the determination of mirabegron and its metabolites in human plasma and their application to a clinical pharmacokinetic study

Raymond van Teijlingen, John Meijer, Shin Takusagawa et al. · Journal of Chromatography B · 2012 · 48 citations

Medicine, Lc–ms/ms Methods, Mass Spectrometry +8

Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β₃-adrenoceptor agonist

Shin Takusagawa, Kanako Yajima, Aiji Miyashita et al. · Xenobiotica · 2012 · 48 citations

Role of Cytochrome P450 Isoenzymes 3A and 2D6 in the In Vivo Metabolism of Mirabegron, a β3-Adrenoceptor Agonist

Jennifer Lee, Selina Moy, John Meijer et al. · Clinical Drug Investigation · 2013 · 39 citations

Molecular Pharmacology, β3-Adrenoceptor Agonist, Biochemistry +8