Lea R. Gamez-Jimenez

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Samuel Obeng, Jenny L. Wilkerson, Francisco León et al. · Journal of Pharmacology and Experimental Therapeutics · 2020 · 102 citations · Full text

Medicine, Pharmacology, Molecular Pharmacology +14

Activity of <i>Mitragyna speciosa</i> (“Kratom”) Alkaloids at Serotonin Receptors

Francisco León, Samuel Obeng, Marco Mottinelli et al. · Journal of Medicinal Chemistry · 2021 · 83 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Interactive Effects of µ-Opioid and Adrenergic-α2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine

Samuel Obeng, Francisco León, Avi Patel et al. · Journal of Pharmacology and Experimental Therapeutics · 2022 · 42 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α2 receptor activity in vitro and in vivo

Samuel Obeng, Morgan L. Crowley, Marco Mottinelli et al. · European Journal of Pharmacology · 2024 · 19 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats

Shyam H. Kamble, Samuel Obeng, Francisco León et al. · Journal of Pharmacology and Experimental Therapeutics · 2023 · 14 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14