Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N. Christo, Maximilien Evrard, Simone L. Park, +23

Nature Immunology

Human CellLineage PlasticityDiscrete Tissue MicroenvironmentsMedicineStem Cell Research +7

Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

Raíssa Fonseca, Thomas N. Burn, Luke C. Gandolfo, +17

Nature Immunology

Cell TherapyMedicineImmunologyCell Replacement TherapyCd4+ T Cells +2

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes

Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, +15

The Journal of Experimental Medicine

Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T‐cell infiltrate

Catherine A. Chapin, Thomas N. Burn, Tomas E. Meijome, +6

Hepatology

Divergent molecular networks program functionally distinct CD8⁺skin-resident memory T cells

Simone L. Park, Susan N. Christo, Alexandria Wells, +24

Science

Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts

Maximilien Evrard, Étienne Becht, Raíssa Fonseca, +17

Immunity

InflammationAutoimmune DiseaseAdaptive Immune SystemMedicineT-regulatory Cell +10

Genetic Deficiency of Interferon‐γ Reveals Interferon‐γ–Independent Manifestations of Murine Hemophagocytic Lymphohistiocytosis

Thomas N. Burn, Lehn K. Weaver, Julia E. Rood, +4

Arthritis & Rheumatology

Clinical ImmunologyImmunodeficienciesImmunologyImmune RegulationPathology +27

Activated CD8 T‐cell Hepatitis in Children With Indeterminate Acute Liver Failure

Catherine A. Chapin, Héctor Melín‐Aldana, Portia A. Kreiger, +11

Journal of Pediatric Gastroenterology and Nutrition

Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency

Andreas Obers, T Poch, Grace Rodrigues, +30

Immunity

TransplantationOphthalmologyRetinoic AcidFibroblast Growth FactorSurgery +1

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

Catarina Gago da Graça, Amania A. Sheikh, Dane M. Newman, +26

Science Immunology