Katharine C. Lai

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

Yelena Kovtun, Charlene A. Audette, Michele Mayo et al. · Cancer Research · 2010 · 259 citations

Medicine, Oncology, Pharmacology +16

Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage

Brenda Kellogg, Lisa M. Garrett, Yelena Kovtun et al. · Bioconjugate Chemistry · 2011 · 210 citations

Pharmacy, Medicinal Chemistry, Oncology +17

A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies

Jutta Deckert, Peter U. Park, Sharon Chicklas et al. · Blood · 2013 · 93 citations

Pharmacy, Oncology, Pharmacology +15

IMGN779, a Novel CD33-Targeting Antibody–Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML

Yelena Kovtun, Paul Noordhuis, Kathleen R. Whiteman et al. · Molecular Cancer Therapeutics · 2018 · 77 citations · Full text

Medicine, Oncology, Pharmacology +13

A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody–Drug Conjugates (ADCs)

Michael L. Miller, Manami Shizuka, Alan Wilhelm et al. · Molecular Cancer Therapeutics · 2018 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14