Alan Wilhelm - Concepedia

Author

Alan Wilhelm

ImmunoGen (United States)

Also Known As

A Wilhelm, A. Wilhelm, Alan J Wilhelm, Alan J. Wilhelm, Alan Wilhelm

Publications

626

Citations

H-Index

Concepts

All Affiliations

ImmunoGen (United States)

About

Alan Wilhelm is an author at ImmunoGen (United States) specializing in medicine, pharmacology, and biomolecular engineering.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	3	3	164
2	Biomolecular Engineering	2	2	136
3	Natural Sciences	1	1	36
4	Allergy	1	1	28
5	Allergy Medicine	1	1	28

Alan Wilhelm

Publications

575

Citations

H-Index

Page 1

	Year	Citations
A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells Yelena Kovtun, Gregory E. Jones, Sharlene Adams, Blood Advances	2018	174
A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity Michael L. Miller, Nathan Fishkin, Wěi Li, Molecular Cancer Therapeutics Tumor-selective DeliveryTumor BiologyMedicinal ChemistryAntibody EngineeringAnti-cancer Agent	2016	100
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody–Drug Conjugates (ADCs) Michael L. Miller, Manami Shizuka, Alan Wilhelm, Molecular Cancer Therapeutics	2018	53
Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers Paulin Salomon, Emily E. Reid, Katie E. Archer, Molecular Pharmaceutics	2019	48
A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation Nicholas C. Yoder, Chen Bai, Daniel Tavares, Molecular Pharmaceutics ImmunologyPharmacotherapyLysine ConjugationMedicinal ChemistryImmunochemistry	2019	36
The Antibody-Drug Conjugate (ADC) IMGN779 Is Highly Active in Vitro and in Vivo Against Acute Myeloid Leukemia (AML) with FLT3-ITD Mutations Kathleen R. Whiteman, Paul Noordhuis, R. Walker, Blood	2014	34
Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody–Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation Chen Bai, Emily E. Reid, Alan Wilhelm, Bioconjugate Chemistry	2019	30
Inhibition of Spleen Tyrosine Kinase Attenuates Allergen-Mediated Airway Constriction Lily Y. Moy, Yanlin Jia, Michael Caniga, American Journal of Respiratory Cell and Molecular Biology AsthmaInflammatory Lung DiseaseLung InflammationAllergy MedicineImmunology	2013	28
Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs) Emily E. Reid, Katie E. Archer, Manami Shizuka, ACS Medicinal Chemistry Letters	2019	20
IMGN632: A CD123-Targeting Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Payload, Is Highly Active and Prolongs Survival in Acute Myeloid Leukemia (AML) Xenograft Models Sharlene Adams, Alan Wilhelm, Lauren Harvey, Blood	2016	17

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