Kasia Mordec

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Robert J. Nichols, Franziska Haderk, Carlos Stahlhut et al. · Nature Cell Biology · 2018 · 418 citations

Medicine, Molecular Biology, Oncology +16

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

Richard Ventura, Kasia Mordec, Joanna Waszczuk et al. · EBioMedicine · 2015 · 296 citations · Full text

Life Sciences, Oncology, Pharmacology +17

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

Timothy S. Heuer, Richard Ventura, Kasia Mordec et al. · EBioMedicine · 2016 · 135 citations · Full text

Medicine, Oncology, Pharmacology +15

Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment

Elsa Quintana, Christopher J. Schulze, Darienne R. Myers et al. · Cancer Research · 2020 · 97 citations

Medicine, Immunology, Oncology +17

Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity

Elena S. Koltun, Naing Aay, Andreas Buckl et al. · Cancer Research · 2018 · 17 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17