The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody

Don M. Benson, Courtney E. Bakan, Anjali Mishra, +14

Blood

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

Susan P. Whitman, Kellie J. Archer, Feng Lin, +10

PubMed

Hematological MalignancyFlt3 GeneMedicineGeneticsAcute Myeloid Leukemia +11

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

Hisashi Harada, Brian Becknell, Matthias Wilm, +5

Molecular Cell

MitophagySignal TransductionMitochondrial FunctionBiochemistryCell Death +6

Evidence for discrete stages of human natural killer cell differentiation in vivo

Aharon G. Freud, Akihiko Yokohama, Brian Becknell, +4

The Journal of Experimental Medicine

Nk Cell DifferentiationHuman CellCell SpecializationLymphocyte DevelopmentHuman Natural Killer +11

A Human CD34(+) Subset Resides in Lymph Nodes and Differentiates into CD56brightNatural Killer Cells

Aharon G. Freud, Brian Becknell, Sameek Roychowdhury, +9

Immunity

Subset ResidesHuman Cd34Lymphocyte DevelopmentImmunologyLymphatic System +7

Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells

Jianhua Yu, Wei Min, Brian Becknell, +15

Immunity

InflammationCytokineInterferon-gamma ProductionAutoimmune DiseaseInnate Immune System +10

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with <i>MLL</i> in acute myeloid leukemia

Peter J. Kourlas, Matthew P. Strout, Brian Becknell, +8

Proceedings of the National Academy of Sciences

Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue

Tiffany Hughes, Brian Becknell, Aharon G. Freud, +11

Immunity

InflammationInterleukin-1β Selectively ExpandsLymphocyte DevelopmentImmune Cell DevelopmentMedicine +11

Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells

Takehito Igarashi, Jason Wynberg, Ramprasad Srinivasan, +7

Blood

Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

Li‐Rong Yu, Jeffrey VanDeusen, Brian Becknell, +10

Nature Genetics

ChromatinCancer Identifies Id4Epigenetic ChangeGeneticsEpigenomics +10