A. Hilpmann

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton, Laura Furst, Richard A. Ruberto et al. · Nature Chemical Biology · 2020 · 472 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +6

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

R.C. Hillig, Brice Sautier, Jens Schroeder et al. · Proceedings of the National Academy of Sciences · 2019 · 379 citations · Full text

Medicine, Molecular Biology, Oncology +17

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

Dieter Moosmayer, A. Hilpmann, Jutta Hoffmann et al. · Acta Crystallographica Section D Structural Biology · 2021 · 117 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

John K. Eaton, Laura Furst, Richard A. Ruberto et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 16 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14