Elias Matouk

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Guido Veit, Ariel Roldán, Mark A. Hancock et al. · JCI Insight · 2020 · 261 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Guido Veit, Haijin Xu, Elise Dréano et al. · Nature Medicine · 2018 · 139 citations

Pharmacy, Medicinal Chemistry, Pharmacotherapy +11

Cystic fibrosis–adapted <i>Pseudomonas aeruginosa</i> quorum sensing <i>lasR</i> mutants cause hyperinflammatory responses

Shantelle L. LaFayette, Daniel Houle, Trevor Beaudoin et al. · Science Advances · 2015 · 132 citations · Full text

Life Sciences, Genetics, Microbiology +17

Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis

Claudine Guilbault, Juan Bautista De Sanctis, Gabriella Wojewodka et al. · American Journal of Respiratory Cell and Molecular Biology · 2007 · 108 citations

Medicine, Biochemistry, Pharmacology +10

Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

Claudine Guilbault, Gabriella Wojewodka, Marián Hajdúch et al. · American Journal of Respiratory Cell and Molecular Biology · 2008 · 99 citations

Life Sciences, Biochemistry, Pharmacology +13