Cystic fibrosis–adapted <i>Pseudomonas aeruginosa</i> quorum sensing <i>lasR</i> mutants cause hyperinflammatory responses

Abstract

mutants have increased plasma interleukin-8 (IL-8), a marker of inflammation. These findings suggest that bacterial adaptive changes may worsen pulmonary inflammation and directly contribute to the pathogenesis and progression of chronic lung disease in CF patients.