Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy, Zahid Bonday, Robert M. Campbell, +14

Proceedings of the National Academy of Sciences

ChromatinCrystal StructureProtein FunctionChromatin StructureBiochemistry +13

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

S Winitz, Marijane Russell, N.X. Qian, +3

Journal of Biological Chemistry

ImmunologyRat 1ACellular PhysiologyMolecular PharmacologySignaling Pathway +18

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD⁺) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

Xun Zhao, Dagart Allison, Bradley Condon, +9

Journal of Medicinal Chemistry

Crystal StructureAldo-keto ReductaseMolecular RegulationMolecular BiologyEpigenetics +18

A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase

S. Atwell, J.M. Adams, John Badger, +16

Journal of Biological Chemistry

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

Marijane Russell, Carol A. Lange, Gary L. Johnson

Journal of Biological Chemistry

SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity <i>in vivo</i>

Sean G. Buchanan, J. Hendle, Patrick S. Lee, +28

Molecular Cancer Therapeutics

Gene AmplificationAntitumor ActivityChemoprevention StrategyExquisite SelectivityCancer Biology +15

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

Stephen Antonysamy, Bradley Condon, Zhanna Druzina, +9

PLoS ONE

Histone ModificationsCrystal StructureEpigenetic ChangeMolecular BiologyNovel Crystal Structure +21

Selective isolation of transiently transfected cells from a mammalian cell population with vectors expressing a membrane anchored single-chain antibody

Jonathan D. Chesnut, Apollo R. Baytan, Marijane Russell, +4

Journal of Immunological Methods

Selective IsolationImmunologyImmunodominanceAntigen ProcessingAntibody Engineering +6

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

J.G. Luz, Stephen Antonysamy, Steven L. Kuklish, +12

Journal of Medicinal Chemistry

Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells

Fiona M. Mitchell, Marijane Russell, Gary L. Johnson

Biochemical Journal

Signal TransductionMolecular PhysiologySynaptic SignalingCarbachol StimulationCell Signaling +13