A SPAK Isoform Switch Modulates Renal Salt Transport and Blood Pressure

James A. McCormick, Kerim Mutig, Joshua H. Nelson, +8

Cell Metabolism

HypertensionUrologyRenal FunctionSodium HomeostasisMedicine +7

Activation of the Bumetanide-sensitive Na+,K+,2Cl− Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

Kerim Mutig, Thomas Kahl, Turgay Saritas, +12

Journal of Biological Chemistry

ImmunologyMolecular BiologyTamm-horsfall ProteinNkcc2 ActivityCellular Physiology +19

Deletion of <i>claudin-10</i> ( <i>Cldn10</i> ) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

Tilman Breiderhoff, Nina Himmerkus, Marchel Stuiver, +7

Proceedings of the National Academy of Sciences

Tight Junction ProteinsCellular PhysiologyParacellular PermeabilityRenal FunctionMembrane Transport +19

A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling

Limei Zhang, Vito S. Hernández, Jerome D. Swinny, +6

Translational Psychiatry

Midbrain Motivation CircuitsSynaptic TransmissionNeurotransmitterLateral HabenulaHypothalamic Circuits +26

Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice

Sebastian Bachmann, Kerim Mutig, James M. Bates, +9

American Journal of Physiology-Renal Physiology

Normal KidneysDecreased Cox-2UrologyRenal FunctionSodium Homeostasis +12

Vasopressin V₂receptor expression along rat, mouse, and human renal epithelia with focus on TAL

Kerim Mutig, Alexander Paliege, T. Kahl, +3

American Journal of Physiology-Renal Physiology

Renal InflammationCellular PhysiologyAdrenal GlandRenal FunctionStrong V +20

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

James A. McCormick, Chao-Ling Yang, Chong Zhang, +17

Journal of Clinical Investigation

<i>WNK1</i> -related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron

Emmanuelle Vidal‐Petiot, Emilie Elvira‐Matelot, Kerim Mutig, +10

Proceedings of the National Academy of Sciences

Tamm-Horsfall Glycoprotein Interacts with Renal Outer Medullary Potassium Channel ROMK2 and Regulates Its Function

Aparna Renigunta, Vijay Renigunta, Turgay Saritas, +3

Journal of Biological Chemistry

Romk Current AmplitudesRenal PathologyCytoskeletonCellular PhysiologyRenal Function +17

Reciprocal Regulation of Aquaporin-2 Abundance and Degradation by Protein Kinase A and p38-MAP Kinase

Pavel I. Nedvetsky, Vedrana Tabor, Grazia Tamma, +10

Journal of the American Society of Nephrology

Cellular PhysiologyProtein Kinase AProtein DegradationCell SignalingOsmoregulation +18