Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Nagaraja Chappidi, Zuzana Naščáková, Barbora Boleslavska, +9

Molecular Cell

Fork Cleavage-religation CycleChromatinTranscriptional RegulationNatural SciencesGenetics +8

Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Martin Andrš, Jan Korábečný, Daniel Jun, +3

Journal of Medicinal Chemistry

Phosphatidylinositol 3-KinaseApoptosisMorpholine RingCell DeathMolecular Biology +17

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Eugenie Nepovimová, Jan Korábečný, Rafael Doležal, +13

Journal of Medicinal Chemistry

Tacrine-trolox HybridsTacrine–trolox HybridsMedicinal ChemistryCentrally ActiveVivo Toxicity +13

7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

Jan Korábečný, Rafael Doležal, Pavla Cabelova, +12

European Journal of Medicinal Chemistry

Molecular PharmacologyQsar Studies7-Meota–donepezil Like CompoundsBiochemistryMedicine +8

Excessive reactive oxygen species induce transcription-dependent replication stress

Martin Andrš, Henriette Stoy, Barbora Boleslavska, +10

Nature Communications

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

Jan Korábečný, Martin Andrš, Eugenie Nepovimová, +11

Molecules

Neurochemical Biomarkers7-Methoxytacrine-p-anisidine HybridsPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +17

DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells

Barbora Boleslavska, Anna Oravetzova, Kaustubh Shukla, +7

Nucleic Acids Research

The development of ataxia telangiectasia mutated kinase inhibitors

Martin Andrš, Jan Korábečný, Eugenie Nepovimová, +5

Mini-Reviews in Medicinal Chemistry

Genome InstabilityOncogenic AgentReceptor Tyrosine KinaseKinase InhibitorsMolecular Biology +11

Novel caffeine derivatives with antiproliferative activity

Martin Andrš, Darina Muthná, Martina Řezáčová, +8

RSC Advances

Dna DamageBiochemistryNovel Caffeine DerivativesMedicinePhysiology +12

MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

Kaustubh Shukla, Michaela Pospíšilová, Christiane König, +6

Science Advances

GeneticsFork StallingMolecular BiologyMolecular GeneticsMutsβ-mutlβ-fancj Axis +15