Ioannis Nicolaou

Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole

Kyriaki Pegklidou, Catherine Koukoulitsa, Ioannis Nicolaou et al. · Bioorganic & Medicinal Chemistry · 2010 · 72 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +13

Substituted Pyrrol-1-ylacetic Acids That Combine Aldose Reductase Enzyme Inhibitory Activity and Ability To Prevent the Nonenzymatic Irreversible Modification of Proteins from Monosaccharides

Ioannis Nicolaou, Vassilis J. Demopoulos · Journal of Medicinal Chemistry · 2002 · 64 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

[1-(3,5-Difluoro-4-hydroxyphenyl)-1<i>H</i>-pyrrol-3-yl]phenylmethanone as a Bioisostere of a Carboxylic Acid Aldose Reductase Inhibitor

Ioannis Nicolaou, Chariklia Zika, Vassilis J. Demopoulos · Journal of Medicinal Chemistry · 2004 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Structure–activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

Maria Chatzopoulou, Eduard Mamadou, Maria Juskova et al. · Bioorganic & Medicinal Chemistry · 2011 · 27 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +11

Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis

Antonios Kousaxidis, Lucia Kováčiková, Ioannis Nicolaou et al. · Medicinal Chemistry Research · 2021 · 27 citations · Full text

Veterinary Medicine, Medicinal Chemistry, Pharmacology +10