Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight

B. Barry Touré, J. Giraldes, Troy Smith, +22

Journal of Medicinal Chemistry

Selective InhibitorsCell CyclePreliminary Biology InsightTumor BiologyEmbryology +15

Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

Kanak Raina, Chris D. Forbes, Rebecca Stronk, +32

Cell chemical biology

Tumor BiologyDrug TargetingMedicineCancer Cell BiologyCancer Selective Therapies +11

Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants

Kathleen M. Frey, D.E. Puleo, Krasimir A. Spasov, +3

Journal of Medicinal Chemistry

Molecular BiologyPeptide ScienceAntiviral DrugChemical BiologyMolecular Pharmacology +17

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders

D.E. Puleo, Kaury Kucera, Henrik M. Hammarén, +5

ACS Medicinal Chemistry Letters

Janus KinasesImmunologyMolecular BiologyChemical BiologyCancer Biology +21

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

Kanak Raina, Chris D. Forbes, Rebecca Stronk, +29

JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules

Ana S. Newton, Luca Deiana, D.E. Puleo, +4

ACS Medicinal Chemistry Letters

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Maria-Elena Liosi, S.G. Krimmer, Ana S. Newton, +6

Journal of Medicinal Chemistry

Atp Binding SiteJanus KinasesMolecular BiologyPseudokinase LigandsChemical Biology +17

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α)

Andrey V. Reshetnyak, Jyotidarsini Mohanty, Francisco Tomé, +8

Proceedings of the National Academy of Sciences

Signaling PathwayReceptor Tyrosine KinaseCell SignalingAug-α DimerizationMolecular Signaling +14

Crystallographic Snapshots of the Complete Catalytic Cycle of the Unregulated Aspartate Transcarbamoylase from Bacillus subtilis

Katharine M. Harris, G.M. Cockrell, D.E. Puleo, +1

Journal of Molecular Biology

Bacillus SubtilisBiochemistryComplete Catalytic CycleBiocatalysisNatural Sciences +5

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant

Ana S. Newton, Maria-Elena Liosi, Sean P. Henry, +6

Tetrahedron Letters