Niels Langkjær

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen, Maria Bach Laursen, A. Nielsen et al. · Nucleic Acids Research · 2009 · 349 citations · Full text

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Jesper B. Bramsen, Malgorzata Maria Pakula, Thomas B. Hansen et al. · Nucleic Acids Research · 2010 · 191 citations · Full text

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

Niels Langkjær, Anna Pasternak, Jesper Wengel · Bioorganic & Medicinal Chemistry · 2009 · 143 citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +8

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

Helge Thisgaard, Joel Kumlin, Niels Langkjær et al. · EJNMMI Radiopharmacy and Chemistry · 2021 · 59 citations · Full text

Filling the gap in LNAantisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′- <i>C</i> -hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

Kees Fluiter, Olaf R.F. Mook, Jeroen Vreijling et al. · Molecular BioSystems · 2009 · 44 citations