Michael E. Fitzsimmons

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

Paul F. Hollenberg, David Edwards, Kan He et al. · UNC Libraries · 2019 · 311 citations · Full text

Agriculture, Pharmacokinetics, Pharmacology +9

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.

Michael E. Fitzsimmons, Jerry M. Collins · PubMed · 1997 · 224 citations

Medicine, Pharmacokinetics, Pharmacology +17

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

Phyllissa Schmiedlin‐Ren, David Edwards, Michael E. Fitzsimmons et al. · PubMed · 1997 · 138 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +10

Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene

Sally J. Hargus, Michael E. Fitzsimmons, Yoko Aniya et al. · Biochemistry · 1991 · 36 citations

Life Sciences, Biochemistry, Chemistry +10

Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues.

Timothy J. Kinsella, Keith A. Kunugi, Kathleen A. Vielhuber et al. · PubMed · 1998 · 26 citations

Medicine, Oncology, Pharmacology +10