Michael E. Fitzsimmons

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.

Michael E. Fitzsimmons, Jerry M. Collins · PubMed · 1997 · 224 citations

Immunology, Pharmacotherapy, Selective Biotransformation +20

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

Phyllissa Schmiedlin‐Ren, David Edwards, Michael E. Fitzsimmons et al. · PubMed · 1997 · 138 citations

Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene

Sally J. Hargus, Michael E. Fitzsimmons, Yoko Aniya et al. · Biochemistry · 1991 · 36 citations

Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues.

Timothy J. Kinsella, Keith A. Kunugi, Kathleen A. Vielhuber et al. · PubMed · 1998 · 26 citations

Chemoprevention Strategy, Ipdr Bolus, Pathology +23

Analysis of inorganic and organic chloramines: derivatization with 2-mercaptobenzothiazole

Marta T. Lukasewycz, Christine M. Bieringer, Robert J. Liukkonen et al. · Environmental Science & Technology · 1989 · 20 citations

Inorganic Chemistry, Environmental Chemistry, Derivative (Chemistry) +11