Gareth W. Langley

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Jürgen Brem, Tharindi Panduwawala, Jon Hansen et al. · Nature Chemistry · 2021 · 77 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Antimicrobial Drug Discovery +11

In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae

Lucas Tselepis, Gareth W. Langley, Ali F. Aboklaish et al. · International Journal of Antimicrobial Agents · 2020 · 48 citations

Medical Microbiology, Global Collection, Antimicrobial Susceptibility +8

Targeting the <i>Mycobacterium tuberculosis</i> transpeptidase Ldt_Mt2 with cysteine-reactive inhibitors including ebselen

Mariska de Munnik, Christopher T. Lohans, Pauline A. Lang et al. · Chemical Communications · 2019 · 38 citations · Full text

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

James P. Holt‐Martyn, Rasheduzzaman Chowdhury, Anthony Tumber et al. · ChemMedChem · 2019 · 29 citations · Full text

Phd Inhibitor, Bioorganic Chemistry, Aldo-keto Reductase +18

A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the <i>Mycobacterium tuberculosis</i> Transpeptidase Ldt_Mt2

Mariska de Munnik, Christopher T. Lohans, Gareth W. Langley et al. · ChemBioChem · 2019 · 26 citations · Full text

Tuberculosis Prevention, Antimicrobial Chemotherapy, Drug Resistance +19