A common glycan structure on immunoglobulin G for enhancement of effector functions

Chin‐Wei Lin, Ming‐Hung Tsai, Shiou‐Ting Li, +24

Proceedings of the National Academy of Sciences

Highly Alpha‐Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides

Che-hsiung Hsu, Kuo‐Ching Chu, Yih‐Shyan Lin, +5

Chemistry - A European Journal

Molecular SieveChemical EngineeringBioorganic ChemistryEngineeringBiochemistry +11

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies

Sachin S. Shivatare, Shih‐Huang Chang, Tsung-I Tsai, +15

Nature Chemistry

BiochemistryMedicineNatural SciencesPeptide LibraryGlycobiology +9

Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells

Yih‐Shyan Lin, Jaeok Park, Joris W. De Schutter, +4

Journal of Medicinal Chemistry

Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV-1 Reverse Transcriptase

Cyrus M. Lacbay, John Mancuso, Yih‐Shyan Lin, +3

Journal of Medicinal Chemistry

Modular AssemblyMolecular BiologyAntiviral DrugModular Synthetic ProtocolPharmaceutical Chemistry +15

Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases

Joris W. De Schutter, Jaeok Park, Chun Yuen Leung, +6

Journal of Medicinal Chemistry

Molecular BiologyNeurochemical BiomarkersChemical BiologyMedicinal ChemistryAlzheimer's Disease +16

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Jaeok Park, Yih‐Shyan Lin, Joris W. De Schutter, +2

BMC Structural Biology

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

Dimitrios Gritzalis, Jaeok Park, Wei Chiu, +7

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesEnzyme CatalysisStructural Elements +8

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls

Joris W. De Schutter, Joseph R. Shaw, Yih‐Shyan Lin, +1

Bioorganic & Medicinal Chemistry

Potent Bisphosphonate InhibitorsTargeted InteractionsBiochemistryMedicineNatural Sciences +7

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Mu‐Chun Li, Mohane Selvaraj Coumar, Shu‐Yu Lin, +16

Journal of Medicinal Chemistry