Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells

Erica P. Cai, Jen‐Kun Lin

Journal of Agricultural and Food Chemistry

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

Erica P. Cai, Yuki Ishikawa, Wei Zhang, +10

Nature Metabolism

Type 1Off-target EffectGeneticsDiabetesBeta Cell Protection +7

Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth

Dan Zhu, Yi Zhang, Patrick Lam, +13

Cell Metabolism

Regulating Insulin ExocytosisDevelopmental BiologyMolecular PhysiologySignal TransductionDual Role +8

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

Sally Yu Shi, Shun-Yan Lu, Tharini Sivasubramaniyam, +12

Nature Communications

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Erica P. Cai, Marina Casimir, Stephanie A. Schroer, +10

Diabetes

Cell AdhesionCytoskeletonGranule TraffickingCellular PhysiologyInsulin Signaling +20

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

Sally Yu Shi, Rubén García-Martín, Robin E. Duncan, +15

Journal of Biological Chemistry

FAK signalling controls insulin sensitivity through regulation of adipocyte survival

Cynthia T. Luk, Sally Yu Shi, Erica P. Cai, +6

Nature Communications

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

Aaron R. Cox, Ornella Barrandon, Erica P. Cai, +7

PLoS ONE

Human GrowthImmunologyImmune RegulationBetatrophin ControversyVariable Quantification +14

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice

Sally Yu Shi, Cynthia T. Luk, Stephanie A. Schroer, +9

Journal of Biological Chemistry

RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

Christopher Contreras, Noyonika Mukherjee, Renato C.S. Branco, +6

Molecular Metabolism