Clinical Practice Guidelines for Pancreatic Cancer 2022 from the Japan Pancreas Society: a synopsis

Takuji Okusaka, Masahiro Yoshida, Masayuki Kitano, +138

International Journal of Clinical Oncology

Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer

Kei Kawaguchi, Kentaro Miyake, Qinghong Han, +14

Cancer Letters

Oral Recombinant MethioninaseOncologyPancreatic CancerMedicineGemcitabine Resistance +4

Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells

Jun Yamamoto, Qinghong Han, Sachiko Inubushi, +9

Biochemical and Biophysical Research Communications

Histone ModificationsChromatinChromatin RemodelingMedicineEpigenetic Change +9

Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model

Takashi Murakami, Shukuan Li, Qinghong Han, +19

Oncotarget

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model

Kei Kawaguchi, Kentaro Igarashi, Shukuan Li, +13

Oncotarget

Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model

Takashi Higuchi, Kei Kawaguchi, Kentaro Miyake, +17

Anticancer Research

Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic

Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, +20

Cell Cycle

Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma

Kentaro Igarashi, Kei Kawaguchi, Shukuan Li, +20

Cancer Letters

Tumor BiologyCancer Cell BiologyFirst-line Dox ResistanceUndifferentiated Spindle-cell SarcomaRadiation Oncology +4

Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention

Kei Kawaguchi, Qinghong Han, Shukuan Li, +15

Cell Cycle

Chemoprevention StrategyBraf-v600e Mutant MelanomaTumor BiologyOncologyElevated Methionine +17

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

Jun Yamamoto, Sachiko Inubushi, Qinghong Han, +10

iScience

OncologyExcess Transmethylation ReactionsMethionine AddictionAddictionMedicine +9