Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Christine Wegler, Fabienne Z. Gaugaz, Tommy B. Andersson, +14

Molecular Pharmaceutics

Metabolomic ProfilingDrug PurityBioanalysisAnalytical ChemistryBiostatistics +20

Global variability analysis of mRNA and protein concentrations across and within human tissues

Christine Wegler, Magnus Ölander, Jacek R. Wiśniewski, +6

NAR Genomics and Bioinformatics

EngineeringGeneticsMultiomicsTranscriptomics TechnologyGene Expression Profiling +16

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

André Mateus, Andrea Treyer, Christine Wegler, +3

Scientific Reports

Direct Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Helen Hammer, Kathrin Klein, Hannes Planatscher, +6

Drug Metabolism and Disposition

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies

Maria Karlgren, Ivailo Simoff, Maria Backlund, +8

Journal of Pharmaceutical Sciences

Improved ToolNatural SciencesMolecular BiologyGenome EngineeringGene Editing +8

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Christine Wegler, Jacek R. Wiśniewski, Ida Robertsen, +7

Clinical Pharmacology & Therapeutics

Drug DispositionMetabolomic ProfilingFatty Liver DiseaseMetabolic ModelMetabolic Syndrome +20

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Jacek R. Wiśniewski, Christine Wegler, Per Artursson

Journal of Proteome Research

Incomplete DigestionTpa MethodMolecular BiologyProteomic TechnologyBioanalysis +20

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Veronica Krogstad, Alexandra Peric, Ida Robertsen, +10

Drug Metabolism and Disposition

Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Kine Eide Kvitne, Veronica Krogstad, Christine Wegler, +16

British Journal of Clinical Pharmacology

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Jacek R. Wiśniewski, Christine Wegler, Per Artursson

Analytical Biochemistry