Ivailo Simoff

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Ivailo Simoff, Maria Karlgren, Maria Backlund et al. · Journal of Pharmaceutical Sciences · 2016 · 64 citations · Full text

Off-target Effect, Natural Sciences, Molecular Biology +9

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>

Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz et al. · Journal of Medicinal Chemistry · 2023 · 51 citations · Full text

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies

Maria Karlgren, Ivailo Simoff, Maria Backlund et al. · Journal of Pharmaceutical Sciences · 2017 · 43 citations

Improved Tool, Natural Sciences, Molecular Biology +10

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate <i>Staphylococcus aureus</i>

Martina Durcik, Andrej Emanuel Cotman, Žan Toplak et al. · Journal of Medicinal Chemistry · 2023 · 34 citations · Full text

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Douglas L. Huseby, Sha Cao, Edouard Zamaratski et al. · Proceedings of the National Academy of Sciences · 2024 · 22 citations · Full text