Synthesis and Antibacterial Activity of Ketolides (6-<i>O</i>-Methyl-3-oxoerythromycin Derivatives):  A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens

Constantin Agouridas, Alexis Denis, Jean-Michel Auger, +12

Journal of Medicinal Chemistry

Bioorganic ChemistryAntibacterial ActivityMacrolactone BackboneKlebsiella PneumoniaeAntimicrobial Chemotherapy +19

Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens

Alexis Denis, Constantin Agouridas, Jean-Michel Auger, +14

Bioorganic & Medicinal Chemistry Letters

AntibioticsHmr 3647Antibacterial ActivityNew KetolideMedicine +8

Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

Philippe Karoyan, Vincent Vieillard, Luis Gómez‐Morales, +6

Communications Biology

Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors

F. Moreau, Nicolas Desroy, Jean-Marie Genevard, +10

Bioorganic & Medicinal Chemistry Letters

MedicineAntibacterial AgentAntimicrobial ChemotherapyMicrobiologyAntimicrobial Compound +5

Towards Gram-negative antivirulence drugs: New inhibitors of HldE kinase

Nicolas Desroy, F. Moreau, Sophia Briet, +7

Bioorganic & Medicinal Chemistry

Hlde KinaseMedicineAntiviral Drug DevelopmentPharmacotherapyPharmacology +2

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

Anne‐Claude Dublanchet, Pierre Ducrot, Charles R. Andrianjara, +11

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicineRational Drug Design +5

Development of a small molecule that corrects misfolding and increases secretion of Z α ₁ ‐antitrypsin

David A. Lomas, James A. Irving, Christopher C. Arico-Muendel, +34

EMBO Molecular Medicine

From Triclosan toward the Clinic: Discovery of Nonbiocidal, Potent FabI Inhibitors for the Treatment of Resistant Bacteria

Vincent Gerusz, Alexis Denis, Fabien Faivre, +20

Journal of Medicinal Chemistry

Bioorganic ChemistryAntibiotic AdjuvantPharmacotherapyAntimicrobial ChemotherapyAntibiotic Resistance +18

β-Keto-ester chemistry and ketolides. synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides

Alexis Denis, François Bretin, C Fromentin, +4

Bioorganic & Medicinal Chemistry Letters

Halogenationβ-Keto-ester ChemistryEngineeringAntibacterial ActivityOrganic Chemistry +5

Dolutegravir as monotherapy in HIV-1-infected individuals with suppressed HIV viraemia

Christine Katlama, Cathia Soulié, Fabienne Caby, +11

Journal of Antimicrobial Chemotherapy