T Naoe

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

G-Q Chen, Jing Zhu, XG Shi et al. · Blood · 1996 · 849 citations · Full text

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

S Yokota, Hitoshi Kiyoi, Makoto Nakao et al. · Leukemia · 1997 · 454 citations

Hematological Malignancy, Chromatin, Flt3 Gene +10

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

Hitoshi Kiyoi, Masayuki Towatari, Shohei Yokota et al. · Leukemia · 1998 · 446 citations

Flt3 Gene, Developmental Biology, Genetic Disorder +8

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

Hitoshi Kiyoi, T Naoe, S Yokota et al. · Leukemia · 1997 · 342 citations

Hematological Malignancy, Mixed-phenotype Acute Leukemia, Malignant Blood Disorder +8

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors

Yukihiro Akao, Yoshihito Nakagawa, I Hirata et al. · Cancer Gene Therapy · 2010 · 260 citations

Oncogenic Agent, Medicine, Colorectal Cancer +10