Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Giulia Siravegna, Benedetta Mussolin, Michela Buscarino, +29

Nature Medicine

MedicinePathologyColorectal CancerColorectal Cancer PatientsEgfr Blockade +4

Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab

Wendy De Roock, Derek J. Jonker, Federica Di Nicolantonio, +15

JAMA

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Giovanni Germano, Simona Lamba, Giuseppe Rospo, +23

Nature

ChromatinGenome InstabilityDna DamageTumour GrowthMedicine +10

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Vito Amodio, Rona Yaeger, Pamela Arcella, +26

Cancer Discovery

Adaptive mutability of colorectal cancers in response to targeted therapies

Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, +20

Science

PathologyCancer BiologyTumor BiologyDrug ResistanceOncology +14

<i>IDH1</i>mutations at residue p.R132 (IDH1^R132) occur frequently in high-grade gliomas but not in other solid tumors

Fonnet E. Bleeker, Simona Lamba, Sieger Leenstra, +14

Human Mutation

EngineeringGeneticsPathologyMolecular BiologyOther Solid Tumors +17

The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

Fonnet E. Bleeker, Nadia A. Atai, Simona Lamba, +8

Acta Neuropathologica

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

Enzo Médico, Mariangela Russo, Gabriele Picco, +16

Nature Communications

Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer

Sandra Misale, Sabrina Arena, Simona Lamba, +14

Science Translational Medicine

High-dose vitamin C enhances cancer immunotherapy

Alessandro Magrì, Giovanni Germano, Annalisa Lorenzato, +12

Science Translational Medicine