8-(3-(<i>R</i>)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Matthias Eckhardt, Elke Langkopf, Michael Mark, +9

Journal of Medicinal Chemistry

Pharmaceutical ScienceXanthine ScaffoldPharmacotherapyPharmaceutical ChemistryTranslational Pharmacology +15

Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)

Gerald J. Roth, Armin Heckel, Florian Colbatzky, +7

Journal of Medicinal Chemistry

Combinatorial ChemistryChemoprevention StrategyTriple Angiokinase InhibitorsPathologyPharmacotherapy +19

Structure elucidation of yersiniabactin, a siderophore from highly virulent <i>Yersinia</i> strains

Hartmut Drechsel, Holger Stephan, Ralf Lotz, +4

Liebigs Annalen

Bioorganic ChemistryMicrobial PathogensBacteriologyNovel SiderophoreYersinia Enterocolitica H1852 +16

Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Thierry Bouyssou, Christoph Hoenke, K Rudolf, +8

Bioorganic & Medicinal Chemistry Letters

Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule

Mirko Koziolek, Michael Grimm, Tabea Bollmann, +5

European Journal of Pharmaceutics and Biopharmaceutics

Animal PhysiologyVeterinary PhysiologyWorking DogAnimal SciencePhysiology +5

Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography–electrospray mass spectrometry

Georgios Piperopoulos, Ralf Lotz, Annette Wixforth, +2

Journal of Chromatography B Biomedical Sciences and Applications

BotanyMedicineMass SpectrometryPlant ExtractsAnalytical Chemistry +5

Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance.

M Dahms, Ralf Lotz, W Lang, +3

PubMed

Metabolomic ProfilingPotential RelevanceSpecies DifferencesMetabolic ModelMetabolic Network +18

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Matthias Eckhardt, Norbert Hauel, Frank Himmelsbach, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryPotent Dpp-4 InhibitorsMedicineNatural Sciences +6

Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood–Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery

Yunhai Cui, Ralf Lotz, Hermann Rapp, +3

Pharmaceutics

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Takashi Yoshikado, Wooin Lee, Kota Toshimoto, +15

Journal of Pharmaceutical Sciences

HepatologyLiver PhysiologyOatp1b SubstratesHistopathologyHepatitis +12