Elke Langkopf

8-(3-(<i>R</i>)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Matthias Eckhardt, Elke Langkopf, Michael Mark et al. · Journal of Medicinal Chemistry · 2007 · 281 citations · Full text

Pharmaceutical Science, Xanthine Scaffold, Pharmacotherapy +17

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors

Leo Thomas, Matthias Eckhardt, Elke Langkopf et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 277 citations

First Studies of the Transition Metal-Catalyzed [5+2] Cycloadditions of Alkenes and Vinylcyclopropanes:  Scope and Stereochemistry

Paul A. Wender, Craig O. Husfeld, Elke Langkopf et al. · Journal of the American Chemical Society · 1998 · 184 citations

First Studies, Chemical Engineering, Engineering +9

Transition Metal-Catalyzed [5 + 2] Cycloadditions of Allenes and Vinylcyclopropanes:  First Studies of Endo−Exo Selectivity, Chemoselectivity, Relative Stereochemistry, and Chirality Transfer

Paul A. Wender, Frank Glorius, Craig O. Husfeld et al. · Journal of the American Chemical Society · 1999 · 165 citations

Chemical Engineering, Enantioselective Synthesis, Engineering +11

β-Catenin and TGFβ signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition

Andreas Eger, Andreas Stockinger, John Park et al. · Oncogene · 2004 · 148 citations

Epithelial-mesenchymal Transition, Developmental Biology, Signal Transduction +11