Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

James F. Callahan, Joelle L. Burgess, James A. Fornwald, +10

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyCell GrowthTumor BiologyGrowth Factor Beta1 +16

Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

William H. Miller, Doreen Alberts, Pradip K. Bhatnagar, +28

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyPharmacodynamic ModelingTranslational PharmacologyPre-clinical Pharmacology +14

Discovery of Potent Nonpeptide Vitronectin Receptor (α_Vβ₃) Antagonists

Richard M. Keenan, William H. Miller, Chet Kwon, +10

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +12

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

James M. Samanen, Fadia E. Ali, Linda S. Barton, +30

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyExperimental PharmacologyPharmacodynamic ModelingTranslational Pharmacology +15

Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles

Dirk A. Heerding, Dennis T. Takata, Chet Kwon, +2

Tetrahedron Letters

Combinatorial ChemistryEngineeringAlkene MetathesisDiels-alder Cycloaddition ReactionOrganic Chemistry +5

Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

William H. Miller, Thomas W. Ku, Fadia E. Ali, +13

Tetrahedron Letters

BiochemistrySb 214857MedicineMechanism Of ActionEnantiospecific Synthesis +4

Structure−Activity Relationships of Novel Hematoregulatory Peptides

Pradip K. Bhatnagar, E Agner, Doreen Alberts, +18

Journal of Medicinal Chemistry

Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics

Richard M. Keenan, William H. Miller, Linda S. Barton, +10

Bioorganic & Medicinal Chemistry Letters

PharmacologyPharmacological AgentPharmacotherapyNon-peptide Ligand2-Aminopyridine Arginine Mimetics +3

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists

William H. Miller, Peter J. Manley, Russell D. Cousins, +22

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmaceutical ScienceIntegrin αVβ3MedicineDrug Discovery +4

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Ligaya M. Simpkins, Scott A. Bolton, Zulan Pi, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmacologyPharmacotherapyNon-peptide LigandDrug Development +4