Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of <i>STAG2</i> and <i>TP53</i> Mutations

Franck Tirode, Didier Surdez, Xiaotu Ma, +19

Cancer Discovery

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Johanna Theruvath, Elena Sotillo, Christopher Mount, +27

Nature Medicine

Cancer ImmunosurveillanceMedicineImmunologyCell TransplantationCancer Treatment +6

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

Thomas G. P. Grünewald, Virginie Bernard, Pascale Gilardi‐Hebenstreit, +29

Nature Genetics

Chimeric Ewsr1-fli1MedicinePathologyCancer GenomicsGgaa Microsatellite +6

Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes

Philippe Podevin, Arnaud Carpentier, Véronique Pène, +15

Gastroenterology

Viral ReplicationHepatologyHepatitis CViral HepatitisLiver Physiology +8

Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution

Marie-Ming Aynaud, Olivier Mirabeau, Nadège Gruel, +19

Cell Reports

Single-cell ResolutionCancer BiologyTumor BiologyEwing SarcomaOncology +14

Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival

Aude Chiot, Sakina Zaïdi, Charlène Iltis, +10

Nature Neuroscience

InflammationAmyotrophic Lateral SclerosisMedicineMicroglial ReactivityImmunology +9

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

Pinar Mesci, Sakina Zaïdi, Christian S. Lobsiger, +6

Brain

STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma

Didier Surdez, Sakina Zaïdi, Sandrine Grossetête, +11

Cancer Cell

Ewing SarcomaMedicineCtcf-anchored Loop ExtrusionCancer GenomicsCell Biology +8

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Cécile Thirant, Agathe Peltier, Simon Durand, +29

Nature Communications

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

Martin F. Orth, Didier Surdez, Tobias Faehling, +21

Cell Reports

Tumor HeterogeneityCancer GenomicsUncovers PrinciplesTumor SuppressorSystems Biology +3