Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Gunther Zimmermann, Bjoern Papke, Shehab Ismail, +8

Nature

Inhibitory ActivitySignal TransductionMolecular RegulationNatural SciencesReceptor Tyrosine Kinase +10

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

Oliver Rocks, Marc Gerauer, Nachiket Vartak, +9

Cell

Proteinlipid InteractionProtein FunctionBiochemistryNatural SciencesPalmitoylation Machinery +10

Small-molecule inhibition of APT1 affects Ras localization and signaling

Frank J. Dekker, Oliver Rocks, Nachiket Vartak, +14

Nature Chemical Biology

Signal TransductionSignaling PathwayG Protein-coupled ReceptorReceptor Tyrosine KinaseSmall-molecule Inhibition +4

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

Malte Schmick, Nachiket Vartak, Bjoern Papke, +4

Cell

Membrane FusionSpatial CyclesMembrane StructureMembrane FormationBiochemistry +11

Cholestasis‐induced adaptive remodeling of interlobular bile ducts

Nachiket Vartak, Amruta Damle‐Vartak, B. Richter, +4

Hepatology

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Wiebke Albrecht, Franziska Kappenberg, Tim Brecklinghaus, +45

Archives of Toxicology

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, +19

Hepatology

The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins

Nachiket Vartak, Bjoern Papke, Hernán E. Grecco, +4

Biophysical Journal

Apt MaintainsProteinlipid InteractionProtein SecretionMolecular BiologyAutodepalmitoylating Activity +16

Development of Highly Potent Inhibitors of the Ras‐Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Christian Hedberg, Frank J. Dekker, Marion Rusch, +7

Angewandte Chemie International Edition

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

Valeska Berg, Marion Rusch, Nachiket Vartak, +8

Blood