Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, +26

Cell stem cell

Cell TherapyCell Replacement TherapyBiomedical EngineeringTherapeuticsStem Cell Biology +22

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, +13

Nature Communications

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

Deirdre B. Hoban, Emer Connaughton, Catherine Connaughton, +5

Brain Behavior and Immunity

Neurodegenerative DiseasesIntra-striatal Lipopolysaccharide AdministrationNeurobiology Of DiseaseLps ModelParkinson Disease +13

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, +7

Cell Reports

Neurodegenerative DiseasesMedicinePreclinical ModelNeurotransmitterParkinson ’ +9

GDNF-secreting mesenchymal stem cells provide localized neuroprotection in an inflammation-driven rat model of Parkinson’s disease

Deirdre B. Hoban, Linda Howard, Eilís Dowd

Neuroscience

Regenerative MedicineMesenchymal Stem CellsNeurodegenerative DiseasesMedicineInflammation-driven Rat Model +11

The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel

Deirdre B. Hoban, Ben Newland, Teresa C. Moloney, +3

Biomaterials

Regenerative MedicineTissue EngineeringNeuroregenerationEngineeringMedicine +11

Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of parkinsonian rats

Tiago Cardoso, Andrew F. Adler, Bengt Mattsson, +7

The Journal of Comparative Neurology

Synaptic TransmissionNeurotransmissionCellular NeurobiologySynaptic SignalingSocial Sciences +20

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, +7

Proceedings of the National Academy of Sciences

Synaptic TransmissionImmunologyTherapeuticsSynaptic SignalingSocial Sciences +19

Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow‐derived mesenchymal stem cells

Teresa C. Moloney, Deirdre B. Hoban, Frank Barry, +2

Protein Science

Cell TherapyImmunologyImmune RegulationThermal TherapyBiomedical Engineering +17

Fibrin-Based Microsphere Reservoirs for Delivery of Neurotrophic Factors to the Brain

Juhi Samal, Deirdre B. Hoban, Carol Naughton, +3

Nanomedicine