Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease

Agnete Kirkeby, Sara Nolbrant, Katarína Tiklová, +10

Cell stem cell

Graft OutcomeNeurochemical BiomarkersTranslational AdvanceSocial SciencesTranslational Medicine +19

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

Olof Torper, Daniella Rylander Ottosson, Maria Pereira, +4

Cell Reports

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, +6

Proceedings of the National Academy of Sciences

EngineeringSynthetic VirologyAav Capsid SurfaceMolecular BiologyViral Structural Protein +16

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, +26

Cell stem cell

Cell TherapyCell Replacement TherapyBiomedical EngineeringTherapeuticsStem Cell Biology +22

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, +13

Nature Communications

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

Shane Grealish, Andreas Heuer, Tiago Cardoso, +6

Stem Cell Reports

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, +7

Cell Reports

Neurodegenerative DiseasesMedicinePreclinical ModelNeurotransmitterParkinson ’ +9

Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of parkinsonian rats

Tiago Cardoso, Andrew F. Adler, Bengt Mattsson, +7

The Journal of Comparative Neurology

Synaptic TransmissionNeurotransmissionCellular NeurobiologySynaptic SignalingSocial Sciences +20

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, +7

Proceedings of the National Academy of Sciences

Synaptic TransmissionImmunologyTherapeuticsSynaptic SignalingSocial Sciences +19

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Daniela Lehnen, Serena Barral, Tiago Cardoso, +9

Stem Cell Reports