Victoria J. Heaton

Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable Complexes In Vitro

Victoria J. Heaton, Jane E. Ambler, L. Mark Fisher · Antimicrobial Agents and Chemotherapy · 2000 · 82 citations · Full text

Identification of Yeast DNA Topoisomerase II Mutants Resistant to the Antitumor Drug Doxorubicin: Implications for the Mechanisms of Doxorubicin Action and Cytotoxicity

Sandhiya Patel, Antje U. Sprung, Beatrice A. Keller et al. · Molecular Pharmacology · 1997 · 47 citations

Activity of Gemifloxacin against Penicillin- and Ciprofloxacin-Resistant <i>Streptococcus pneumoniae</i> Displaying Topoisomerase- and Efflux-Mediated Resistance Mechanisms

Victoria J. Heaton, Colin E. Goldsmith, Jane E. Ambler et al. · Antimicrobial Agents and Chemotherapy · 1999 · 38 citations · Full text

Molecular cloning and characterization of the human topoisomerase IIα and IIβ genes: evidence for isoform evolution through gene duplication 1Sequences described here have been submitted to the EMBL/GenBank databases under accession nos. AJ011721–AJ011732 and AJ011741–AJ011758. Part of this work was presented as a poster at the Fourth Conference on DNA Topoisomerases in Therapy, New York, 1992: J.-H. Sng, C.A. Austin, L.M. Fisher. Cloning the human topoisomerase IIα gene. Abstract P03. 1

Jen-Hwei Sng, Victoria J. Heaton, Margaret Bell et al. · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 1999 · 28 citations

Human Topoisomerase Iiα, Dna Topoisomerases, Translational Biology +5