L. Mark Fisher

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae

Xiao-Su Pan, Jane E. Ambler, Shaheen Mehtar et al. · Antimicrobial Agents and Chemotherapy · 1996 · 436 citations · Full text

Ciprofloxacin Targets, Pare Subunits, Molecular Biology +19

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

Ivan Laponogov, Maninder K. Sohi, Dennis A. Veselkov et al. · Nature Structural & Molecular Biology · 2009 · 289 citations

Biochemistry, Natural Sciences, Type Iia Topoisomerases +5

DNA gyrase action involves the introduction of transient double-strand breaks into DNA.

Kiyoshi Mizuuchi, L. Mark Fisher, M H O'Dea et al. · Proceedings of the National Academy of Sciences · 1980 · 238 citations · Full text

Dna Damage, Dna, Dna Analysis +17

<i>Mycobacterium tuberculosis</i> DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity

Alexandra Aubry, Xiao-Su Pan, L. Mark Fisher et al. · Antimicrobial Agents and Chemotherapy · 2004 · 233 citations · Full text

Tuberculosis Prevention, Bacteriology, Molecular Biology +22

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones

Xiao-Su Pan, L. Mark Fisher · Antimicrobial Agents and Chemotherapy · 1997 · 231 citations · Full text

Antibiotic Adjuvant, Molecular Biology, Selective Targeting +20