Jane E. Ambler

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae

Xiao-Su Pan, Jane E. Ambler, Shaheen Mehtar et al. · Antimicrobial Agents and Chemotherapy · 1996 · 436 citations · Full text

Ciprofloxacin Targets, Pare Subunits, Molecular Biology +19

Potent Antipneumococcal Activity of Gemifloxacin Is Associated with Dual Targeting of Gyrase and Topoisomerase IV, an In Vivo Target Preference for Gyrase, and Enhanced Stabilization of Cleavable Complexes In Vitro

Victoria J. Heaton, Jane E. Ambler, L. Mark Fisher · Antimicrobial Agents and Chemotherapy · 2000 · 82 citations · Full text

Molecular characterization of MRSA isolates bracketing the current EUCAST ceftaroline-susceptible breakpoint for<i>Staphylococcus aureus</i>: the role of PBP2a in the activity of ceftaroline

Sushmita D. Lahiri, Robert E. McLaughlin, James Whiteaker et al. · Journal of Antimicrobial Chemotherapy · 2015 · 45 citations · Full text

Fluoroquinolone Resistance in <i>Streptococcus pneumoniae</i> : Evidence That <i>gyrA</i> Mutations Arise at a Lower Rate and That Mutation in <i>gyrA</i> or <i>parC</i> Predisposes to Further Mutation

Stephen H. Gillespie, LeRoy L. Voelker, Jane E. Ambler et al. · Microbial Drug Resistance · 2003 · 43 citations

<i>In Vitro</i> Activity of Ceftaroline against Staphylococcus aureus Isolated in 2012 from Asia-Pacific Countries as Part of the AWARE Surveillance Program

Douglas J. Biedenbach, Richard A. Alm, Sushmita D. Lahiri et al. · Antimicrobial Agents and Chemotherapy · 2015 · 41 citations · Full text