Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

Kenji Maeda, K. Anand, Antonella Chiapparino, +4

Nature

Signal TransductionInteractome Map UncoversBiochemistryNatural SciencesMolecular Biology +5

Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions

Damiano Fantini, Carlo Vascotto, Daniela Marasco, +10

Nucleic Acids Research

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Lisa Lirussi, Giulia Antoniali, Carlo Vascotto, +9

Molecular Biology of the Cell

Dna DamageGeneticsApoptosisMolecular BiologyEpigenetics +17

Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins

Mattia Poletto, Lisa Lirussi, David M. Wilson, +1

Molecular Biology of the Cell

Molecular BiologyCell DeathCytoskeletonEpigeneticsProtein Synthesis +19

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

Mattia Poletto, Matilde Clarissa Malfatti, Dorjbal Dorjsuren, +8

Molecular Carcinogenesis

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology

Carlo Vascotto, Lisa Lirussi, Mattia Poletto, +7

Oncogene

ChromatinCell RegulationBiochemistryMolecular RegulationNatural Sciences +9

G-quadruplex DNA recognition by nucleophosmin: New insights from protein dissection

Pasqualina Liana Scognamiglio, Concetta Di Natale, Marilisa Leone, +4

Biochimica et Biophysica Acta (BBA) - General Subjects

Dna SequencingStructural BioinformaticsMolecular Biological MethodProtein FoldingMedicine +10

p53 coordinates base excision repair to prevent genomic instability

Mattia Poletto, Arnaud J. Legrand, Sally C. Fletcher, +1

Nucleic Acids Research

Genome InstabilityGenome SurgeryNatural SciencesGeneticsGenomic Mechanism +13

Expression and Prognostic Significance of APE1/Ref-1 and NPM1 Proteins in High-Grade Ovarian Serous Cancer

Ambrogio P. Londero, Maria ­Orsaria, Gianluca Tell, +6

American Journal of Clinical Pathology

Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)

Mattia Poletto, Carlo Vascotto, Pasqualina Liana Scognamiglio, +3

Biochemical Journal

GeneticsHape1 BindingEssential EnzymeMolecular BiologyTranscriptional Regulation +15