Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, +10

Nature Communications

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Lisa Lirussi, Giulia Antoniali, Carlo Vascotto, +9

Molecular Biology of the Cell

Dna DamageGeneticsApoptosisMolecular BiologyEpigenetics +17

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements

Giulia Antoniali, Lisa Lirussi, Chiara DˈAmbrosio, +7

Molecular Biology of the Cell

Sirt1 PromoterGeneticsGenomic MechanismCell DeathEpigenetics +15

Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins

Mattia Poletto, Lisa Lirussi, David M. Wilson, +1

Molecular Biology of the Cell

Molecular BiologyCell DeathCytoskeletonEpigeneticsProtein Synthesis +19

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology

Carlo Vascotto, Lisa Lirussi, Mattia Poletto, +7

Oncogene

ChromatinCell RegulationBiochemistryMolecular RegulationNatural Sciences +9

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

Lene Alsøe, Antonio Sarno, Sergio Carracedo, +13

Scientific Reports

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia

Pasqualina Liana Scognamiglio, Concetta Di Natale, Marilisa Leone, +9

Oncotarget

Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin)

Mattia Poletto, Carlo Vascotto, Pasqualina Liana Scognamiglio, +3

Biochemical Journal

GeneticsHape1 BindingEssential EnzymeMolecular BiologyTranscriptional Regulation +15

SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing

Penelope Kroustallaki, Lisa Lirussi, Sergio Carracedo, +8

Cell Reports

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation

Lisa Lirussi, Giulia Antoniali, Chiara DˈAmbrosio, +3

Oncotarget